Serie A’s fifth round begins on Friday 18 September, when Monza host Sassuolo at 20:45, and concludes on Sunday 20 September with Milan against Lecce. Across the weekend, midfield selection will again be central to fantasy managers weighing established leaders against players whose minutes remain less certain.
Serie A Matchday 5 Midfield Picks: Who to Start and Who to Avoid
The leading group contains players expected to offer the strongest combination of reliability and attacking potential. Davide Frattesi, Adrien Rabiot, Nico Paz, Kevin De Bruyne, Nicolò Barella, Francisco Conceição, Martin Baturina, Luka Mora, Moreira and Franco Mastantuono form the top tier for the round.
A second group brings midfielders capable of delivering sound performances and possible returns, even if they sit a step below the foremost selections. It includes Niccolò Pisilli, Neil El Aynaoui Diouf, Cisse, Arthur Atta Ekkelenkamp, Piotr Zielinski, Nikola Vlasic, Mattia Zaccagni, Petar Sucic, Edon Zhegrova, Luka Modric, Lucas Da Cunha, Daniel Maldini, Federico Bernardeschi, Ederson, Vergara, Albert Gudmundsson, Manu Koné, Vasilije Adzic, Matteo Politano and Yunus Musah.
Midfielders for a More Cautious Call
The next bracket is made up of players who could secure a passing grade and potentially provide an unexpected contribution, although they are not among the first names in the pecking order for this matchday. Rolando Mandragora, Lassana Coulibaly, Simone Calò, Taylor, Bryan Cristante, Teun Koopmeiners, Maxence Caqueret, Matteo Perrone, Marten de Roon, Stanislav Lobotka, Samuel Chukwueze, Billy Gilmour, Kristian Thorstvedt, Tommaso Pobega, Tommaso Baldanzi, Nemanja Matic, Romano, Cacciamani, Atta and Franck Kessié belong in this category.
For the final group, the concern is either a difficult fixture or the possibility of receiving no playing-time rating at all. Jashari, Douglas Luiz, Ndour, Konaté, Maleh, Kike Perez, Cichella, Moro, Oulai, Akinsanmiro, Ilkhan, Keita, Ordonez, Masini, Fabbian, Karlstrom, Lipani, Folorunsho and Sow are the midfielders to approach with greater restraint.
With Milan-Lecce bringing the curtain down on the round, the fifth weekend offers another early indication of which squads can turn midfield depth into a sustained advantage over the season.
SEO Title: Serie A Matchday 5 Midfield Picks: Frattesi, De Bruyne and Barella Lead
SEO Description: Serie A Matchday 5 opens with Monza-Sassuolo and ends with Milan-Lecce. Review the midfield tiers, from Frattesi and De Bruyne to the riskier selections.



